The Tundra 45 is the better everyday buy unless you need more capacity or a lower price.
Both coolers use rotomolded construction, thick foam insulation, and heavy-duty rubber or silicone latches to lock in ice for days. The YETI Tundra 45 pulls ahead for most buyers because it is meaningfully lighter empty (about 24.6 lbs versus roughly 29.5 lbs for the RTIC), which matters every single time you lift it in and out of a truck bed or down a dock. YETI also backs the Tundra line with a certified bear-resistant rating and includes a dry goods basket standard, so there is nothing extra to buy before your first trip.
RTIC 45 is still the right call if raw capacity or built-in conveniences matter more than shaving weight. Its 60-can and 41-lb ice capacity beat the Tundra 45's 54 cans and 37 lbs of ice, its interior cavity is larger in every dimension, and it adds a built-in stainless bottle opener, a silicone cargo net in the lid, and a dual-plug Rapid V-Drain system the Tundra 45 does not have. The trade-off is close to 5 extra pounds of empty weight and no bear-resistant certification claim.